                         SEQUENCE LISTING



<110>  Stratagene



<120>  HIGH FIDELITY DNA POLYMERASE COMPOSITIONS AND USES THEREFOR



<130>  25436/2158



<160>  127   



<170>  PatentIn version 3.1



<210>  1

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  MISC_FEATURE

<222>  (2)..(3)

<223>  X at potision 2 or 3 is any amino acid.



<400>  1

Asp Xaa Xaa Ser Leu Tyr Pro 
1               5           


<210>  2

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  MISC_FEATURE

<222>  (2)..(7)

<223>  X at position 2, 3, 4, or 7 is any amino acid.



<400>  2

Lys Xaa Xaa Xaa Asn Ser Xaa Tyr Gly 
1               5                   


<210>  3

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  misc_feature

<222>  (2)..(3)

<223>  X at position 2 or 3 is any amino acid.



<400>  3

Thr Xaa Xaa Gly Arg 
1               5   


<210>  4

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  MISC_FEATURE

<222>  (2)..(2)

<223>  X at position 2 is any amino acid.



<400>  4

Tyr Xaa Asp Thr Asp Ser 
1               5       


<210>  5

<211>  3

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  misc_feature

<222>  (2)..(2)

<223>  X at position 2 is any amino acid.



<400>  5

Lys Xaa Tyr 
1           


<210>  6

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  MISC_FEATURE

<222>  (2)..(2)

<223>  X at position 2 is any amino acid. 



<400>  6

Tyr Xaa Gly Gly 
1               


<210>  7

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<400>  7

Ser Tyr Thr Gly Gly Phe 
1               5       


<210>  8

<211>  23

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<400>  8
gaggagagca ggaaaggtgg aag                                             23


<210>  9

<211>  23

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<400>  9
gaggtacagg gttgaggcta ctg                                             23


<210>  10

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(6)

<223>  Consensus sequence



<400>  10

Ser Tyr Ala Gly Gly Tyr 
1               5       


<210>  11

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(6)

<223>  Consensus sequence



<400>  11

Ser Tyr Glu Gly Gly Tyr 
1               5       


<210>  12

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(6)

<223>  Consensus sequence



<400>  12

Thr Tyr Leu Gly Gly Tyr 
1               5       


<210>  13

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(7)

<223>  Consensus sequence



<400>  13

Asp Phe Arg Ala Leu Tyr Pro 
1               5           


<210>  14

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(6)

<223>  Consensus sequence



<400>  14

Tyr Ile Asp Thr Asp Gly 
1               5       


<210>  15

<211>  3

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(3)

<223>  Consensus sequence



<400>  15

Lys Arg Tyr 
1           


<210>  16

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(6)

<223>  Consensus sequence



<400>  16

Tyr Ser Asp Thr Asp Gly 
1               5       


<210>  17

<211>  3

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(3)

<223>  Consensus sequence



<400>  17

Lys Arg Tyr 
1           


<210>  18

<211>  3

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Consensus sequence

<220>

<221>  DOMAIN

<222>  (1)..(3)

<223>  Consensus sequence



<400>  18

Lys Lys Tyr 
1           


<210>  19

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  19

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  20

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  20

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Asn Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  21

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  21

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Leu Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  22

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  22

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


His Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  23

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  23

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Gln Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  24

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  24

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Ser Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  25

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  25

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Ser Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  26

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  26

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Pro Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  27

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  27

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Ala Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  28

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  28

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Pro Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  29

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  29

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  30

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  30

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Asn 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  31

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  31

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Leu 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  32

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  32

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser His 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  33

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  33

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Gln 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  34

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  34

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Ser 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  35

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  35

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Ser Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  36

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  36

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Pro Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  37

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  37

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Ala Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  38

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  38

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Pro Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  39

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  39

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  40

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  40

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Asn 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  41

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  41

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Leu 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  42

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  42

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser His 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  43

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  43

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Gln 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  44

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  44

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Ser 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  45

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  45

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Ser Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  46

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  46

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Pro Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  47

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  47

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Ala Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  48

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  48

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Pro Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  49

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  49

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  50

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  50

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Asn Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  51

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  51

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Leu Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  52

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  52

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr His Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  53

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  53

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Gln Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  54

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  54

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Ser Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  55

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  55

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Ser Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  56

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  56

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Pro Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  57

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  57

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Ala Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  58

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  58

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Pro Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  59

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  59

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  60

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  60

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Asn Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  61

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  61

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Leu Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  62

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  62

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


His Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  63

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  63

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Gln Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  64

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  64

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Ser Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  65

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  65

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Ser Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  66

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  66

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Pro Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  67

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  67

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Ala Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  68

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  68

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Pro Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  69

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  69

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Glu Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  70

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  70

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Pro Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  71

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  71

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Gly Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  72

<211>  775

<212>  PRT

<213>  Pyrococcus furiosus



<400>  72

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Thr Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  73

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  73

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Glu Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  74

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  74

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Pro Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  75

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  75

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Gly Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  76

<211>  773

<212>  PRT

<213>  Thermococcus gorgonarius



<400>  76

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Thr 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  77

<211>  773

<212>  PRT

<213>  Pyrococcus sp.



<400>  77

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Glu Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly 
    770             


<210>  78

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  78

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Pro Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  79

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  79

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Gly Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  80

<211>  774

<212>  PRT

<213>  Pyrococcus sp.



<400>  80

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Thr 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  81

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  81

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Glu Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  82

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  82

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Pro 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  83

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  83

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Gly Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  84

<211>  774

<212>  PRT

<213>  Thermococcus litoralis



<400>  84

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Thr Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  85

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  85

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Glu Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  86

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  86

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Pro Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  87

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  87

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Gly Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  88

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  88

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Thr Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  89

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<400>  89
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  90

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1153)..(1155)

<223>  Ns at position 1153 to 1155 may be any nucleotides so that the co
       don at 1153-1155 encodes for Asn, Leu, His, Gln, or Ser.  



<400>  90
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gcnnnacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  91

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1159)..(1161)

<223>  Ns at position 1159-1161 may ne any nucleotide so that the codon 
       at 1159-1161 encodes Ser or Pro.



<400>  91
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacann nggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  92

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1162)..(1164)

<223>  Ns at position 1162-1164 may be any nucleotides so that the codon
        at 1162-1164 encodes for Ala or Pro.



<400>  92
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tnnnttcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  93

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1213)..(1215)

<223>  Ns at position 1213-1215 may be any nucleotides so that the codon
        at 1213-1215 encodes for Glu.



<400>  93
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tannntttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  94

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1624)..(1626)

<223>  Ns at position 1624-1626 may be any nucleotides so that the codon
        at 1624-1626 encodes Pro.



<400>  94
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacnnngatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  95

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1627)..(1629)

<223>  Ns at position 1627-1629 may be any nucleotides so that the codon
        at 1627-1629 encodes for Gly.



<400>  95
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactnnng gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  96

<211>  2328

<212>  DNA

<213>  Pyrococcus furiosus



<220>

<221>  misc_feature

<222>  (1777)..(1779)

<223>  Ns at position 1777-1779 may be any nucleotides so that the codon
        at 1777-1779 encodes for Thr.



<400>  96
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa     60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct    120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga    180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt    240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt    300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac    360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc    420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt    480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac    540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag    600

aaggatcctg acattatagt tacttataat ggagactcat tcgcattccc atatttagcg    660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag    720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg    780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa    840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa    900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat    960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct   1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa   1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg   1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac   1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct   1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac   1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa   1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt   1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat   1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag   1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt   1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag   1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat   1740

gaagggtttt ataagagggg attcttcgtt acgaagnnna ggtatgcagt aatagatgaa   1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca   1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct   1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag   1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac   2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt   2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa   2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca tggagaacca ggttcttcca   2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag   2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                2328


<210>  97

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<400>  97
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  98

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1150)..(1152)

<223>  Ns at positions 1150-1152 may be any nucleotides so that the codo
       n at 1150-1152 encodes for Asn, Leu, His, Gln, or Ser.



<400>  98
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagcn nngaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  99

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1156)..(1158)

<223>  Ns at position 1156-1158 may be any nucleotides so that the codon
        at 1156-1158 encodes for Ser or Pro.  



<400>  99
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaannngg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  100

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1159)..(1161)

<223>  Ns at position 1159-1161 may be any nucleotides so that the codon
        at 1159-1161 encodes for Ala or Pro.  



<400>  100
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggann ntatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  101

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1210)..(1212)

<223>  Ns at positions 1210-1212 may be any nucleotides so that the codo
       n at 1210-1212 encodes for Glu.



<400>  101
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctan nntttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  102

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1621)..(1623)

<223>  Ns at positions 1621-1623 may be any nucleotides so that the codo
       n at 1621-1623 encodes for Pro.



<400>  102
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

nnngacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  103

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1624)..(1626)

<223>  Ns at positions 1624-1626 may be any nucleotides so that the codo
       n at 1624-1626 encodes for Gly.



<400>  103
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accnnnggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  104

<211>  2325

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1774)..(1776)

<223>  Ns at positions 1774-1776 may be any nucleotides so that the codo
       n at 1774-1776 encodes for Thr.



<400>  104
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag     60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc    120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg    180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt    240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata    300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac    360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc    420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata    480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac    540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag    600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa    660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag    720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc    780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa    840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa    900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac    960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc   1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag   1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga   1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata   1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg   1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc   1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg   1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat   1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca   1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac   1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac   1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct   1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag   1740

ggcttctaca aacgcggctt cttcgtcacg aagnnnaagt atgcggtgat agacgaggaa   1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa   1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg   1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg   1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt   2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc   2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc   2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc   2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg   2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                   2325


<210>  105

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<400>  105
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  106

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1159)..(1161)

<223>  Ns at positions 1159-1161 may be any nucleotides so that the codo
       n at 1159-1161 encodes for Asn, Leu, His, Gln, or Ser.



<400>  106
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactnn nctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  107

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1165)..(1167)

<223>  Ns at positions 1165-1167 may be any nucleotides so that the codo
       n at 1165-1167 encodes for Ser or Pro.  



<400>  107
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgnnngga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  108

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1168)..(1170)

<223>  Ns at positions 1168-1170 may be any nucleotides so that the codo
       n at 1168-1170 encodes for Ala, or Pro.



<400>  108
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggannn tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  109

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1219)..(1221)

<223>  Ns at positions 1219-1221 may be any nucleotides so that the codo
       n at 1219-1221 encodes for Glu.



<400>  109
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgnn nttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  110

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1630)..(1632)

<223>  Ns at positions 1630-1632 may be any nucleotides so that the codo
       n at 1630-1632 encodes for Pro.



<400>  110
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggacn nngacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  111

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1633)..(1635)

<223>  Ns at positions 1633-1635 may be any nucleotides so that the codo
       n at 1633-1635 encodes for Gly.



<400>  111
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctnnnggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aaaagcgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  112

<211>  2325

<212>  DNA

<213>  Thermococcus litoralis



<220>

<221>  misc_feature

<222>  (1783)..(1785)

<223>  Ns at positions 1783-1785 may be any nucleotides so that the codo
       n at 1783-1785 encodes for Thr.



<400>  112
atgatactgg acactgatta cataacaaaa gatggcaagc ctataatccg aatttttaag     60

aaagagaacg gggagtttaa aatagaactt gaccctcatt ttcagcccta tatatatgct    120

cttctcaaag atgactccgc tattgaggag ataaaggcaa taaagggcga gagacatgga    180

aaaactgtga gagtgctcga tgcagtgaaa gtcaggaaaa aatttttggg aagggaagtt    240

gaagtctgga agctcatttt cgagcatccc caagacgttc cagctatgcg gggcaaaata    300

agggaacatc cagctgtggt tgacatttac gaatatgaca taccctttgc caagcgttat    360

ctcatagaca agggcttgat tcccatggag ggagacgagg agcttaagct ccttgccttt    420

gatattgaaa cgttttatca tgagggagat gaatttggaa agggcgagat aataatgatt    480

agttatgccg atgaagaaga ggccagagta atcacatgga aaaatatcga tttgccgtat    540

gtcgatgttg tgtccaatga aagagaaatg ataaagcgtt ttgttcaagt tgttaaagaa    600

aaagaccccg atgtgataat aacttacaat ggggacaatt ttgatttgcc gtatctcata    660

aaacgggcag aaaagctggg agttcggctt gtcttaggaa gggacaaaga acatcccgaa    720

cccaagattc agaggatggg tgatagtttt gctgtggaaa tcaagggtag aatccacttt    780

gatcttttcc cagttgtgcg aaggacgata aacctcccaa cgtatacgct tgaggcagtt    840

tatgaagcag ttttaggaaa aaccaaaagc aaattaggag cagaggaaat tgccgctata    900

tgggaaacag aagaaagcat gaaaaaacta gcccagtact caatggaaga tgctagggca    960

acgtatgagc tcgggaagga attcttcccc atggaagctg agctggcaaa gctgataggt   1020

caaagtgtat gggacgtctc gagatcaagc accggcaacc tcgtggagtg gtatctttta   1080

agggtggcat acgcgaggaa tgaacttgca ccgaacaaac ctgatgagga agagtataaa   1140

cggcgcttaa gaacaactta cctgggagga tatgtaaaag agccagaaaa aggtttgtgg   1200

gaaaatatca tttatttgga tttccgcagt ctgtaccctt caataatagt tactcacaac   1260

gtatccccag atacccttga aaaagagggc tgtaagaatt acgatgttgc tccgatagta   1320

ggatataggt tctgcaagga ctttccgggc tttattccct ccatactcgg ggacttaatt   1380

gcaatgaggc aagatataaa gaagaaaatg aaatccacaa ttgacccgat cgaaaagaaa   1440

atgctcgatt ataggcaaag ggctattaaa ttgcttgcaa acagctatta cggctatatg   1500

gggtatccta aggcaagatg gtactcgaag gaatgtgctg aaagcgttac cgcatggggg   1560

agacactaca tagagatgac gataagagaa atagaggaaa agttcggctt taaggttctt   1620

tatgcggaca ctgacggctt ttatgccaca atacccgggg aaaagcctga actcattaaa   1680

aagaaagcca aggaattcct aaactacata aactccaaac ttccaggtct gcttgagctt   1740

gagtatgagg gcttttactt gagaggattc tttgttacaa aannncgcta tgcagtcata   1800

gatgaagagg gcaggataac aacaaggggc ttggaagtag taaggagaga ttggagtgag   1860

atagctaagg agactcaggc aaaggtttta gaggctatac ttaaagaggg aagtgttgaa   1920

aaagctgtag aagttgttag agatgttgta gagaaaatag caaaatacag ggttccactt   1980

gaaaagcttg ttatccatga gcagattacc agggatttaa aggactacaa agccattggc   2040

cctcatgtcg cgatagcaaa aagacttgcc gcaagaggga taaaagtgaa accgggcaca   2100

ataataagct atatcgttct caaagggagc ggaaagataa gcgatagggt aattttactt   2160

acagaatacg atcctagaaa acacaagtac gatccggact actacataga aaaccaagtt   2220

ttgccggcag tacttaggat actcgaagcg tttggataca gaaaggagga tttaaggtat   2280

caaagctcaa aacaaaccgg cttagatgca tggctcaaga ggtag                   2325


<210>  113

<211>  775

<212>  PRT

<213>  Pyrococcus sp.



<400>  113

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


<210>  114

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1153)..(1155)

<223>  Ns at positions 1153-1155 may be any nucleotides so that the codo
       n at 1153-1155 encodes for Asn, Leu, His, Gln, or Ser.



<400>  114
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gcnnngctgg gggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacagatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  115

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1159)..(1161)

<223>  Ns at positions 1159-1161 may be any nucleotides so that the codo
       n at 1159-1161 encodes for Ser or Pro.



<400>  115
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctnn nggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacagatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  116

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1162)..(1164)

<223>  Ns at positions 1162-1164 may be any nucleotides so that the codo
       n at 1162-1164 encodes for Ala or Pro.



<400>  116
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctgg gnnntacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacagatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  117

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1213)..(1215)

<223>  Ns at positions 1213-1215 may be any nucleotides so that the codo
       n at 1213-1215 encodes for Glu.



<400>  117
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctgg gggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tannnttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacagatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  118

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1624)..(1626)

<223>  Ns at positions 1624-1626 may be any nucleotides so that the codo
       n at 1624-1626 encodes for Pro.



<400>  118
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctgg gggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacnnngatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  119

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1627)..(1629)

<223>  Ns at positions 1627-1629 may be any nucleotides so that the codo
       n at 1627-1629 encodes for Gly.



<400>  119
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctgg gggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacannng gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagaaga agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  120

<211>  2328

<212>  DNA

<213>  Pyrococcus sp.



<220>

<221>  misc_feature

<222>  (1777)..(1779)

<223>  Ns at positions 1777-1779 may be any nucleotides so that the codo
       n at 1777-1779 encodes for Thr.



<400>  120
atgatacttg acgctgacta catcaccgag gatgggaagc cgattataag gattttcaag     60

aaagaaaacg gcgagtttaa ggttgagtac gacagaaact ttagacctta catttacgct    120

ctcctcaaag atgactcgca gattgatgag gttaggaaga taaccgccga gaggcatggg    180

aagatagtga gaattataga tgccgaaaag gtaaggaaga agttcctggg gaggccgatt    240

gaggtatgga ggctgtactt tgaacaccct caggacgttc ccgcaataag ggataagata    300

agagagcatt ccgcagttat tgacatcttt gagtacgaca ttccgttcgc gaagaggtac    360

ctaatagaca aaggcctaat tccaatggaa ggcgatgaag agctcaagtt gctcgcattt    420

gacatagaaa ccctctatca cgaaggggag gagttcgcga aggggcccat tataatgata    480

agctatgctg atgaggaaga agccaaagtc ataacgtgga aaaagatcga tctcccgtac    540

gtcgaggtag tttccagcga gagggagatg ataaagcggt tcctcaaggt gataagggag    600

aaagatcccg atgttataat tacctacaac ggcgattctt tcgaccttcc ctatctagtt    660

aagagggccg aaaagctcgg gataaagcta cccctgggaa gggacggtag tgagccaaag    720

atgcagaggc ttggggatat gacagcggtg gagataaagg gaaggataca ctttgacctc    780

taccacgtga ttaggagaac gataaacctc ccaacataca ccctcgaggc agtttatgag    840

gcaatcttcg gaaagccaaa ggagaaagtt tacgctcacg agatagctga ggcctgggag    900

actggaaagg gactggagag agttgcaaag tattcaatgg aggatgcaaa ggtaacgtac    960

gagctcggta gggagttctt cccaatggag gcccagcttt caaggttagt cggccagccc   1020

ctgtgggatg tttctaggtc ttcaactggc aacttggtgg agtggtacct cctcaggaag   1080

gcctacgaga ggaatgaatt ggctccaaac aagccggatg agagggagta cgagagaagg   1140

ctaagggaga gctacgctgg gggatacgtt aaggagccgg agaaagggct ctgggagggg   1200

ttagtttccc tagatttcag gagcctgtac ccctcgataa taatcaccca taacgtctca   1260

ccggatacgc tgaacaggga agggtgtagg gaatacgatg tcgccccaga ggttgggcac   1320

aagttctgca aggacttccc ggggtttatc cccagcctgc tcaagaggtt attggatgaa   1380

aggcaagaaa taaaaaggaa gatgaaagct tctaaagacc caatcgagaa gaagatgctt   1440

gattacaggc aacgggcaat caaaatcctg gcaaacagct attatgggta ttatgggtac   1500

gcaaaagccc gttggtactg taaggagtgc gcagagagcg ttacggcctg ggggagggaa   1560

tatatagagt tcgtaaggaa ggaactggag gaaaagttcg ggttcaaagt cttatacata   1620

gacacagatg gactctacgc cacaattcct ggggcaaaac ccgaggagat aaagaagaaa   1680

gccctagagt tcgtagatta tataaacgcc aagctcccag ggctgttgga gcttgagtac   1740

gagggcttct acgtgagagg gttcttcgtg acgaagnnna agtatgcgtt gatagatgag   1800

gaagggaaga taatcactag ggggcttgaa atagtcagga gggactggag cgaaatagcc   1860

aaagaaaccc aagcaaaagt cctagaggct atcctaaagc atggcaacgt tgaggaggca   1920

gtaaagatag ttaaggaggt aactgaaaag ctgagcaagt acgaaatacc tccagaaaag   1980

ctagttattt acgagcagat cacgaggccc cttcacgagt acaaggctat aggtccgcac   2040

gttgccgtgg caaaaaggtt agccgctaga ggagtaaagg tgaggcctgg catggtgata   2100

gggtacatag tgctgagggg agacgggcca ataagcaaga gggctatcct tgcagaggag   2160

ttcgatctca ggaagcataa gtatgacgct gagtattaca tagaaaatca ggttttacct   2220

gccgttctta gaatattaga ggcctttggg tacaggaaag aagacctcag gtggcagaag   2280

actaaacaga caggtcttac ggcatggctt aacatcaaga agaagtaa                2328


<210>  121

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1150)..(1152)

<223>  Ns at positions 1150-1152 may be any nucleotides so that the codo
       n at 1150-1152 encodes for Asn, Leu, His, Gln, or Ser.



<400>  121
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagcn nngcgggtgg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acagatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  122

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1156)..(1158)

<223>  Ns at positions 1156-1158 may be any nucleotides so that codon at
        1156-1158 encodes for Ser or Pro.



<400>  122
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgnnngg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acagatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  123

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1159)..(1161)

<223>  Ns at positions 1159-1161 may be any nucleotides so that the codo
       n at 1159-1161 encodes for Ala or Pro.



<400>  123
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgggtnn ntacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acagatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  124

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1210)..(1212)

<223>  Ns at positions 1210-1212 may be any nucleotides so that the codo
       n at 1210-1212 encodes for Glu.



<400>  124
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgggtgg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgn nnttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acagatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  125

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1621)..(1623)

<223>  Ns at positions 1621-1623 may be any nucleotides so that the codo
       n at 1621-1623 encodes for Pro.



<400>  125
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgggtgg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

nnngatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  126

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1624)..(1626)

<223>  Ns at positions 1624-1626 may be any nucleotides so that the codo
       n at 1624-1626 encodes for Gly.



<400>  126
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgggtgg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acannnggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagaagaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


<210>  127

<211>  2322

<212>  DNA

<213>  Thermococcus gorgonarius



<220>

<221>  misc_feature

<222>  (1774)..(1776)

<223>  Ns at positions 1774-1776 may be any nucleotides so that the codo
       n at 1774-1776 encodes for Thr.



<400>  127
atgatcctcg atacagacta cataactgag gatggaaagc ccgtcatcag gatcttcaag     60

aaggagaacg gcgagttcac catagactac gacagaaact ttgagccata catctacgcg    120

ctcttgaagg acgactctcc gattgaggac gtcaagaaga taactgccga gaggcacggc    180

actaccgtta gggttgtcag ggccgagaaa gtgaagaaga agttcctagg caggccgata    240

gaggtctgga agctctactt cactcacccc caggacgttc ccgcaatcag ggacaagata    300

aaggagcatc ctgccgttgt ggacatctac gagtacgaca tccccttcgc gaagcgctac    360

ctcatagaca aaggcttaat cccgatggag ggcgacgagg aacttaagat gctcgccttc    420

gacatcgaga cgctctatca cgagggcgag gagttcgccg aagggcctat cctgatgata    480

agctacgccg acgaggaagg ggcgcgcgtt attacctgga agaatatcga ccttccctat    540

gtcgacgtcg tttccaccga gaaggagatg ataaagcgct tcctcaaggt cgtcaaggaa    600

aaggatcccg acgtcctcat aatctacaac ggcgacaact tcgacttcgc ctacctcaag    660

aagcgctccg agaagctcgg agtcaagttc atcctcggaa gggaagggag cgaaccgaaa    720

atccagcgca tgggcgatcg ctttgcggtg gaggtcaagg gaaggattca cttcgacctc    780

taccccgtca ttaggagaac gattaacctc cccacttaca cccttgaggc agtatatgaa    840

gccatctttg gacagccgaa ggagaaggtc tacgctgagg agatagcgca ggcctgggaa    900

acgggcgagg gattagaaag ggtggcccgc tactcgatgg aggacgcgaa ggtaacctat    960

gaactcggaa aagagttctt ccctatggaa gcccagctct cgcgcctcgt aggccagagc   1020

ctctgggatg tatctcgctc gagtaccgga aacctcgtcg agtggttttt gctgaggaag   1080

gcctacgaga ggaatgaact tgcaccaaac aagccggacg agagggagct ggcaagaaga   1140

agggagagct acgcgggtgg atacgtcaag gagcccgaaa ggggactgtg ggagaacatc   1200

gtgtatctgg acttccgctc cctgtatcct tcgataataa tcacccataa cgtctcccct   1260

gatacactca acagggaggg ttgtgaggag tacgacgtgg ctcctcaggt aggccataag   1320

ttctgcaagg acttccccgg cttcatccca agcctcctcg gagacctctt ggaggagaga   1380

cagaaggtaa agaagaagat gaaggccact atagacccaa tcgagaagaa actcctcgat   1440

tacaggcaac gagcaatcaa aatccttgct aatagcttct acggttacta cggctataca   1500

aaggcccgct ggtactacaa ggagtgcgcc gagagcgtta ccggttgggg cagggagtac   1560

atcgagacca cgataaggga aatagaggag aaatttggct ttaaagtcct ctacgcggac   1620

acagatggat ttttcgcaac aatacctgga gcggacgccg aaaccgtcaa aaagaaggca   1680

aaggagttcc tggactacat caacgccaaa ctgcccggcc tgctcgaact cgaatacgag   1740

ggcttctaca agcgcggctt cttcgtgacg aagnnnaagt acgcggttat agacgaggag   1800

gacaagataa cgacgcgcgg gcttgaaata gttaggcgtg actggagcga gatagcgaag   1860

gagacgcagg cgagggttct tgaggcgata ctaaagcacg gtgacgttga agaagcggta   1920

aggattgtca aagaggttac ggagaagctg agcaagtacg aggttccacc ggagaagctg   1980

gtcatctacg agcagataac ccgcgacctg aaggactaca aggccaccgg gccgcatgtg   2040

gctgttgcaa aacgcctcgc cgcaaggggg ataaaaatcc ggcccggaac ggtcataagc   2100

tacatcgtgc tcaaaggctc gggaaggatt ggggacaggg ctataccctt tgacgaattt   2160

gacccggcaa agcacaagta cgatgcagaa tactacatcg agaaccaggt tcttccagct   2220

gtggagagga ttctgagggc ctttggttac cgtaaagaag atttaaggta tcagaaaacg   2280

cggcaggttg gcttgggggc gtggctaaaa cctaagacat ga                      2322


